Chapter 6: PrEP: Prevention in a Pill
Armor You Take
π Session Overview
Duration: 75-90 minutes
Part: Part III - Medical Shields: Pills and Shots that Protect
MATCH Connection: Medications (M)
π― Learning Objectives
- Understand what PrEP is and how it works to prevent HIV
- Know the effectiveness rates: >99% for sexual transmission when taken consistently
- Identify who should consider taking PrEP
- Learn the 3 steps to get started with PrEP
- Understand that PrEP ONLY prevents HIV, not other STIs
- Address common myths and stigma around PrEP use
- Know where to access PrEP locally and affordably
π‘ Key Concepts from the Ebook
- What is PrEP: Pre-Exposure Prophylaxis - daily pill for HIV-negative people to prevent HIV
- Effectiveness: Over 99% effective for sexual transmission, 74% for injection drug use
- The Golden Rule: PrEP only works if you take it - consistency is key
- Not a substitute for condoms: Prevents HIV only, not other STIs or pregnancy
- Who should consider: HIV-negative people at higher risk (inconsistent condom use, HIV+ partner, recent STI, injection drug use)
- Getting started: Talk to doctor β Get tested β Regular follow-ups every 3 months
π¦ Materials Needed
- Sample PrEP pill bottle (empty or prop)
- Handout: "Am I a Good Candidate for PrEP?" checklist
- Handout: Local PrEP providers and resources
- Poster or slides: How PrEP works (visual diagram)
- Myth-busting cards
- Whiteboard and markers
- Optional: Guest speaker - someone currently on PrEP (with their consent)
- Links to PrEP locator tools (preplocator.org)
π Opening Activity (10 minutes)
PrEP Myths: True or False
Purpose: Surface and address stigma and misinformation about PrEP.
| Statement | Answer | Reality |
| "PrEP is only for promiscuous people" |
FALSE |
PrEP is for anyone at risk, including people in relationships with HIV+ partners |
| "PrEP is 100% effective" |
MOSTLY TRUE |
>99% effective for sex when taken daily; consistency matters |
| "PrEP causes serious side effects" |
FALSE |
Most people have no side effects; mild nausea possible at first |
| "You can skip PrEP on days you're not having sex" |
FALSE |
Daily adherence ensures consistent protection; skipping reduces effectiveness |
| "PrEP protects against all STIs" |
FALSE |
ONLY prevents HIV; still need barriers for other STIs |
π Core Content (35 minutes)
"PrEP (Pre-Exposure Prophylaxis) is one of the most powerful medical tools in the modern safER sex toolkit. It is a daily pill taken by HIV-negative people to prevent them from contracting HIV. Think of it as a daily armor that, when taken consistently, provides a highly effective barrier against the virus."
Part 1: How PrEP Works (10 minutes)
From the ebook: "PrEP medications contain two drugs that are also used to treat HIV. When taken regularly, these drugs build up a protective shield in the body. If HIV enters the bloodstream, the medication prevents the virus from replicating and establishing a permanent infection."
π‘οΈ PrEP = Daily Armor
Think of it like this:
- Taking PrEP daily = building a fortress wall, brick by brick
- HIV exposure = enemy attack on the wall
- The wall is strong enough to keep the enemy out
- Miss too many doses = gaps in the wall = virus can get through
Active Ingredients:
- Truvada (brand name): Combination of tenofovir + emtricitabine
- Descovy (newer option): Tenofovir alafenamide + emtricitabine
- Generic versions now available = more affordable
Part 2: Effectiveness - The Power of Consistency (8 minutes)
β‘ The Golden Rule (from the ebook):
"PrEP only works if you take it. Consistency is the key to its power."
| Transmission Route |
Effectiveness |
Key Factor |
| Sexual Transmission |
Over 99% effective |
Daily adherence critical |
| Injection Drug Use |
At least 74% effective |
Higher with consistent use |
Real-world data: When taken 4+ times per week, PrEP provides strong protection. 7 days per week = maximum protection.
Part 3: Who Should Consider PrEP? (7 minutes)
From the ebook: "PrEP is recommended for anyone who is HIV-negative and at a higher risk of contracting HIV."
You might be a good candidate if you:
- Have an HIV-positive partner who is not virally suppressed (U=U)
- Do not consistently use condoms
- Have been diagnosed with an STI in the past six months
- Use injection drugs
- Are in a sexual network where HIV is prevalent
- Want an extra layer of protection for peace of mind
Important Clarification
PrEP is NOT just for "high-risk" people. It's for anyone who wants to take control of their HIV prevention. Even people in monogamous relationships use PrEP for added confidence.
Part 4: Getting Started with PrEP (10 minutes)
The 3-Step Process (from the ebook):
| Step |
What Happens |
Why It Matters |
| 1. Talk to Your Doctor |
Discuss sexual history, lifestyle, and whether PrEP is right for you |
PrEP requires a prescription; doctor assesses candidacy |
| 2. Get Tested |
HIV test (must be negative to start), Hepatitis B test, kidney function test |
Ensures PrEP is safe for you and establishes baseline |
| 3. Regular Follow-Up |
Every 3 months: HIV test, STI screening, prescription refill, check-in |
Monitors effectiveness, catches any issues early, maintains protection |
Cost & Access:
- Most insurance covers PrEP at little to no cost
- Patient assistance programs: Gilead Advancing Access, manufacturer copay cards
- Community health centers often provide PrEP on sliding scale
- PrEP locator tool: preplocator.org or pluspills.com
Part 5: What PrEP Does NOT Do (Critical!) (5 minutes)
β οΈ From the Ebook:
"It is essential to remember that PrEP only protects against HIV. It does not protect against other STIs (like syphilis, gonorrhea, chlamydia, or HPV) or prevent pregnancy. For comprehensive safER sex, PrEP is best used in combination with condoms and regular STI testing."
PrEP is ONE piece of your MATCH framework:
- Medications = PrEP β
- Tools = Still need condoms for STIs
- Awareness = Regular testing for other STIs
- Communication = Discuss PrEP status with partners
- Habits = Daily pill routine, 3-month checkups
π¬ Discussion Questions (15 minutes)
Facilitate Group Discussion:
- What stigma or judgment have you heard about people who take PrEP?
- Unpack: "Truvada whore" slur, assumptions about sexual behavior, respectability politics
- Why do you think PrEP uptake is still lower than it could be, given its effectiveness?
- Barriers: Stigma, cost perception, lack of awareness, provider reluctance, systemic racism
- How would you explain PrEP to a friend who's never heard of it?
- Practice: Brief, clear, shame-free explanation
- What questions would you want answered before starting PrEP?
- Capture: Side effects, drug interactions, lifestyle changes, partner disclosure
π¨ Interactive Activity (15 minutes)
"Am I a Candidate?" Self-Assessment
Purpose: Help participants evaluate whether PrEP might be right for them.
Instructions: Provide worksheet with yes/no questions. Participants complete anonymously.
Sample Questions:
- Are you HIV-negative (or unsure of your status)?
- Do you have a sexual partner who is HIV-positive?
- Do you sometimes have sex without using condoms?
- Have you had an STI in the past 6 months?
- Do you inject drugs and share needles/works?
- Would having extra protection give you peace of mind during sex?
- Are you willing to take a daily pill and do 3-month checkups?
Scoring: "Yes" to 2+ questions = consider talking to a doctor about PrEP
Debrief: Emphasize this is self-reflection, not judgment. Provide list of local PrEP providers for those interested.
π Closing & Reflection (10 minutes)
Chapter 6 Takeaway
"PrEP is a revolutionary tool that puts the power of HIV prevention directly into your hands. It is a choice that allows you to pursue pleasure with confidence and significantly reduce your risk of contracting HIV. Talk to your doctorβit could be the most important safER sex decision you make."
PrEP Quick Facts
- Effectiveness: >99% for sexual transmission with daily use
- Cost: Often free with insurance; assistance programs available
- Side effects: Mild nausea in some people during first month; usually resolves
- Time to protection: 7 days of daily pills for receptive anal; 21 days for vaginal
- Testing requirement: Every 3 months while on PrEP
Reflection Prompt:
"Whether or not PrEP is right for you, what's one thing you learned today that changed your understanding of HIV prevention?"
Take-Home Challenge
- Research one local PrEP provider (clinic, doctor, telehealth)
- If considering PrEP: Write down 3 questions to ask a doctor
- Share accurate PrEP info with one person who might benefit
- Challenge stigma: If you hear "Truvada whore" or similar slurs, educate
π Preview Next Session
Next: Chapter 7: PEP: The 72-Hour Windowβthe emergency option when prevention didn't happen. We'll cover when to use PEP, the critical 72-hour window, and how to access it fast.
Resources to Share
- PrEP Locator: preplocator.org or pluspills.com
- Financial Assistance: Gilead Advancing Access (gileadadvancingaccess.com)
- Telehealth PrEP: MISTR, Nurx, PlushCare, Folx Health
- CDC PrEP Info: cdc.gov/prep
- Community Resources: Local LGBTQ+ health centers, Planned Parenthood
HARNESS Curriculum | Chapter 6 Complete Lesson Plan
Β© Christopher Zacharie | Fearless, Aware, and Protected